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Experts say that laughter is the best medicine. After all, it increases your immune system response, lowers blood sugar levels in diabetics, increases oxygen flow throughout your entire body and helps induce a state of relaxation promoting better sleep. The positive health effects are no laughing matter: according to the University of Maryland Medical Center, average blood flow typically increases 22 percent during and after bursts of laughter compared to a decrease in blood flow by 35 percent during mental stress.